Prediction of binding hot spot residues by using structural and evolutionary parameters
Genet. mol. biol
; Genet. mol. biol;32(3): 626-633, 2009. ilus, graf
Article
em En
| LILACS
| ID: lil-522334
Biblioteca responsável:
BR26.1
ABSTRACT
In this work, we present a method for predicting hot spot residues by using a set of structural and evolutionary parameters. Unlike previous studies, we use a set of parameters which do not depend on the structure of the protein in complex, so that the predictor can also be used when the interface region is unknown. Despite the fact that no information concerning proteins in complex is used for prediction, the application of the method to a compiled dataset described in the literature achieved a performance of 60.4 percent, as measured by F-Measure, corresponding to a recall of 78.1 percent and a precision of 49.5 percent. This result is higher than those reported by previous studies using the same data set.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Sítios de Ligação
/
Proteínas
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Genet. mol. biol
Assunto da revista:
GENETICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil