Innate immunity and regulatory T-cells in human Chagas disease: what must be understood?

Sathler-Avelar, Renato; Vitelli-Avelar, Danielle Marquete; Teixeira-Carvalho, Andréa; Martins-Filho, Olindo Assis

Sathler-Avelar, Renato; Vitelli-Avelar, Danielle Marquete; Teixeira-Carvalho, Andréa; Martins-Filho, Olindo Assis.

Afiliação

Sathler-Avelar, Renato; FIOCRUZ. CPqRR. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte. BR
Vitelli-Avelar, Danielle Marquete; FIOCRUZ. CPqRR. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte. BR
Teixeira-Carvalho, Andréa; FIOCRUZ. CPqRR. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte. BR
Martins-Filho, Olindo Assis; FIOCRUZ. CPqRR. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte. BR

Mem. Inst. Oswaldo Cruz ; 104(supl.1): 246-251, July 2009.

Article em En | LILACS | ID: lil-520885

Biblioteca responsável: BR1.1

ABSTRACT

ABSTRACT

There is a general consensus that during chronic Trypanosoma cruzi infection, the host immune system induces complex processes to ensure the control of parasite growth while preserving the potential to mount and maintain a life-long controlled humoral and cellular immune response against the invading pathogen. This review summarises evidence in an attempt to elucidate "what must be understood" to further clarify the role of innate immunity in the development/maintenance of clinical Chagas disease and the impact of etiological treatment on host immunity, highlighting the contributions of the innate immunity and regulatory T (Treg) cells. Recently, increasing focus on innate immunity suggest that chronic T. cruzi infection may cause morbidity when innate effector functions, or the down-regulation of adaptive regulatory mechanisms are lacking. In this context, stable asymptomatic host-parasite interactions seem to be influenced by the effector/regulatory balance with the participation of macrophages, natural killer (NK) and CD8+ T cells in parallel with the establishment of regulatory mechanisms mediated by NKT and Treg cells. Moreover, a balanced innate immune activation state, apart from Treg cells, may play a role in controlling the adverse events triggered by the massive antigen release induced by trypanosomicidal agents during Chagas disease etiological treatment.

Assuntos

Humanos; Doença de Chagas/imunologia; Interações Hospedeiro-Parasita/imunologia; Imunidade Inata/imunologia; Linfócitos T Reguladores/imunologia; Trypanosoma cruzi/imunologia; /imunologia; Doença Crônica; Células Matadoras Naturais/imunologia; Macrófagos/imunologia; Trypanosoma cruzi/crescimento & desenvolvimento

Palavras-chave

Human Chagas disease; Innate immunity; Regulatory T-cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Trypanosoma cruzi / Doença de Chagas / Linfócitos T Reguladores / Interações Hospedeiro-Parasita / Imunidade Inata Limite: Humans Idioma: En Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: MEDICINA TROPICAL / PARASITOLOGIA Ano de publicação: 2009 Tipo de documento: Article / Project document País de afiliação: Brasil País de publicação: Brasil

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