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Plasticity in primary somatosensory cortex resulting from environmentally enriched stimulation and sensory discrimination training
Guic, Eliana; Carrasco, Ximena; Rodríguez, Eugenio; Robles, Ignacio; Merzenich, Michael M.
Afiliação
  • Guic, Eliana; Pontificia Universidad Católica de Chile. Faculty of Social Sciences. Department of Psychology. CL
  • Carrasco, Ximena; Universidad de Chile. School of Medicine. Department of Pediatrics. CL
  • Rodríguez, Eugenio; Pontificia Universidad Católica de Chile. Faculty of Social Sciences. Department of Psychology. CL
  • Robles, Ignacio; Universidad de Chile. School of Medicine. Department of Surgery Hospital del Salvador. CL
  • Merzenich, Michael M; UCSF. Keck Center for Integrative Neurosciences. San Francisco. US
Biol. Res ; 41(4): 425-437, Dec. 2008. ilus, tab
Article em En | LILACS | ID: lil-518398
Biblioteca responsável: BR1.1
ABSTRACT
We studied primary-somatosensory cortical plasticity due to selective stimulation of the sensory periphery by two procedures of active exploration in adult rats. Subjects, left with only three adjacent whiskers, were trained in a roughness discrimination task or maintained in a tactile enriched environment. Either training or enrichment produced 3-fold increases in the barrel cortex areas of behaviorally-engaged whisker representations, in their zones of overlap. While the overall areas of representation expanded dramatically, the domains of exclusive principal whisker responses were virtually identical in enriched vs normal rats and were significantly smaller than either group in roughness discrimination-trained rats. When animals were trained or exposed to enriched environments with the three whiskers arrayed in an are or row, very equivalent overlaps in representations were recorded across their greatly-enlarged whisker representation zones. This equivalence in distortion in these behavioral preparations is in contradistinction to the normal rat, where overlap is strongly biased only along rows, probably reflecting the establishment of different relations with the neighboring cortical columns. Overall, plasticity phenomena are argued to be consistent with the predictions of competitive Hebbian network plasticity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Córtex Somatossensorial / Aprendizagem por Discriminação / Meio Ambiente / Comportamento Exploratório / Plasticidade Neuronal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biol. Res Assunto da revista: BIOLOGIA Ano de publicação: 2008 Tipo de documento: Article / Project document País de afiliação: Chile / Estados Unidos País de publicação: Chile
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Córtex Somatossensorial / Aprendizagem por Discriminação / Meio Ambiente / Comportamento Exploratório / Plasticidade Neuronal Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biol. Res Assunto da revista: BIOLOGIA Ano de publicação: 2008 Tipo de documento: Article / Project document País de afiliação: Chile / Estados Unidos País de publicação: Chile