Nuclear calcium signaling: a cell within a cell
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;42(1): 17-20, Jan. 2009. ilus
Article
em En
| LILACS
| ID: lil-505417
Biblioteca responsável:
BR1.1
ABSTRACT
Calcium (Ca2+) is a versatile second messenger that regulates a wide range of cellular functions. Although it is not established how a single second messenger coordinates diverse effects within a cell, there is increasing evidence that the spatial patterns of Ca2+ signals may determine their specificity. Ca2+ signaling patterns can vary in different regions of the cell and Ca2+ signals in nuclear and cytoplasmic compartments have been reported to occur independently. No general paradigm has been established yet to explain whether, how, or when Ca2+ signals are initiated within the nucleus or their function. Here we highlight that receptor tyrosine kinases rapidly translocate to the nucleus. Ca2+ signals that are induced by growth factors result from phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol 1,4,5-trisphosphate formation within the nucleus rather than within the cytoplasm. This novel signaling mechanism may be responsible for growth factor effects on cell proliferation.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Núcleo Celular
/
Receptores Proteína Tirosina Quinases
/
Sinalização do Cálcio
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Proliferação de Células
Limite:
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2009
Tipo de documento:
Article
/
Congress and conference
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Project document
País de afiliação:
Brasil
/
Estados Unidos
País de publicação:
Brasil