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Gastrointestinal manifestations as initial presentation of acute leukemias in children and adolescents / Manifestaciones gastrointestinales como presentación de las leucemias agudas en niños y adolescentes
Robazzi, Teresa C. M. V; Silva, Luciana R; Mendonça, Núbia; Barreto, José H. S.
Afiliação
  • Robazzi, Teresa C. M. V; Federal University of Bahia. Department of Pediatric. BR
  • Silva, Luciana R; Federal University of Bahia. Discipline of Pediatrics and Head of Pediatric Gastroenterology and Hepatology Service. BR
  • Mendonça, Núbia; Bahia Oncology Society Ltda. ONCO. Head of Pediatric Oncology Unit Dr. Jorge Bahia deCarvalho. Salvador. BR
  • Barreto, José H. S; Epidemiology Commitee of Brazilian Pediatric Oncology Society. BR
Acta gastroenterol. latinoam ; Acta gastroenterol. latinoam;38(2): 126-132, jun. 2008. tab
Article em En | LILACS | ID: lil-503617
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVE:

this study aimed to determine the prevalence and characteristics of gastrointestinal manifestations on initial clinical presentation of acute leukemias (AL) in childhood. MATERIAL AND

METHODS:

this is a retrospective and descriptive study that assessed medical records of 354 patients with AL from January 1995 to December 2004.

RESULTS:

acute lymphoid leukemia (ALL) was diagnosed in 273 (77.1%) patients and acute non-lymphocytic leukemia (AML) in 81 (22.9%). There were 210 males (59.4%) and 144 females (40.6%). The most common presenting features were abdominal pain (19.5% in ALL and 11.8% in AML), nausea and vomiting (14.9 in ALL and 14% in AML), abdominal distention (18.5 in ALL and 8.6% in AML; p 0.024), constipation (5% in ALL and 6.5% in AML), diarrhea (3.6% in ALL and 11.8% in AML; p 0.03%), and gastrointestinal bleeding (7.9% in ALL and 9.7% in AML). Ultrasound scanning was made in 61.1% and hepatomegaly was found on 33.6% and esplenomegaly on 28.5% of the patients with AL. Seventy-seven (21.7%) and 15 (4.2%) patients received nonsteroidal anti-inflammatory drugs and glucocorticoids before the diagnostic of AL. An association is well-defined between abdominal symptoms like nausea, vomiting and pain and use of this therapy but this association did not occurred clearly in this study.

CONCLUSIONS:

gastrointestinal symptoms are not very well-documented as initial manifestation of leukemia in children and should be considered on the differential diagnosis of gastrointestinal symptoms of unknown etiology in children.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Leucemia Mieloide Aguda / Leucemia-Linfoma Linfoblástico de Células Precursoras / Gastroenteropatias Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Acta gastroenterol. latinoam Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Argentina
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Leucemia Mieloide Aguda / Leucemia-Linfoma Linfoblástico de Células Precursoras / Gastroenteropatias Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Acta gastroenterol. latinoam Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Argentina