Estudios citogenéticos en niños con Leucemia Linfocitica Aguda-B en Costa Rica / Cytogenetic studies in children with Acute Lymphocitic Leukemia-B in Costa Rica
Rev. biol. trop
; Rev. biol. trop;52(3): 551-558, sept. 2004.
Article
em Es
| LILACS
| ID: lil-501725
Biblioteca responsável:
BR1.1
ABSTRACT
Chromosome analyses were performed on bone marrow of 177 pediatric patients with Acute Lymphocitic Leukemia at the [quot ]Hospital Nacional de Nifios[quot ]. The standard cytogenetic techniques now belongs to the panel of mandatory analyses performed at diagnosis of our acute leukemia patients and represent a major advantage to be effective and independent prognostic factors, essential for therapeutic choices. Cytogenetic results were achieved in 83% of the bone marrow samples normal karyotypes represented 29% and abnormal karyotypes 71% with the follow distribution t (9;22) 3%; t (l;19) 5%; t (4;11) 3%, Hyperdiploidy 39%; other chromosomal abnormalities 21%. Systematic cytogenetic analyses are essencial to define morpho-immunologic sub-types of leukemia and to detect new translocations that allows to understand hematopoiesis and leukemogenesis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Medula Óssea
/
Aberrações Cromossômicas
/
Linfoma de Burkitt
Tipo de estudo:
Prognostic_studies
Limite:
Humans
País/Região como assunto:
America central
/
Costa rica
Idioma:
Es
Revista:
Rev. biol. trop
Assunto da revista:
BIOLOGIA
/
MEDICINA TROPICAL
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Costa Rica
País de publicação:
Costa Rica