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Diagnostic methods for prevention of anal cancer and characteristics of anal lesions caused by HPV in men with HIV/AIDS
Pereira, Araiz Cajueiro Carneiro; Lacerda, Heloísa Ramos de; Barros, Romualda Castro do Rêgo.
Afiliação
  • Pereira, Araiz Cajueiro Carneiro; Federal University of Pernambuco. University Hospital. Infectious and Parasitic Diseases Clinic. Recife. BR
  • Lacerda, Heloísa Ramos de; Federal University of Pernambuco. University Hospital. Infectious and Parasitic Diseases Clinic. Recife. BR
  • Barros, Romualda Castro do Rêgo; Federal University of Pernambuco. University Hospital. Infectious and Parasitic Diseases Clinic. Recife. BR
Braz. j. infect. dis ; Braz. j. infect. dis;12(4): 293-299, Aug. 2008. ilus, tab
Article em En | LILACS | ID: lil-496766
Biblioteca responsável: BR1.1
ABSTRACT
Abnormalities found with anuscopy under colposcopic vision, anal cytology and anal biopsy were evaluated in 21 men with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) at the Federal University of Pernambuco Hospital in Brazil. Mean age was 38.4 ± 6.0 years, and mean time of HIV infection was 8.3 ± 5.1 years; 95.2 percent of the patients had been on highly active antiretroviral therapy (HAART) for an average of 6.6 ± 4.5 years. Mean CD4+ cell count was 482.2 ± 173.75 cells/mm³, and 80.9 percent presented a HIV viral load of < 5,000 copies/mL. Reported sexual preference was 52.4 percent homosexuals, 28.6 percent bisexuals, and 19.0 percentheterosexuals; 81 percent reported having had receptive anal intercourse and 61.9 percent reported more than 10 sexual partners of the same sex. Results of anuscopy under colposcopic vision revealed 17 (81.0 percent) low-grade lesions and/or condylomata or micropapillae and four (19.0 percent) high-grade lesions with or without condylomata. Among the 21 anal cytology examinations, seven (33.3 percent) revealed low-grade squamous intraepithelial lesions (LSIL); three (14.3 percent) presented atypical squamous cells of undetermined significance (ASCUS) and 11 (52.4 percent) were normal. Seventeen patients were submitted to anal biopsy with the following

findings:

three patients (17.6 percent) with normal epithelium, one (5.9 percent) with infection by HPV, three (17.6 percent) with condylomatas, two (11.8 percent) with AIN 1, four (23.6 percent) with AIN 2, three (17.6 percent) with AIN 3, and one (5.9 percent) with PAIN 2. Anuscopy under colposcopic vision was found to be useful for detecting anal lesions and for guiding anal biopsies. Anal cytology was less useful, as it underestimated the frequency of lesions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Doenças do Ânus / Neoplasias do Ânus / Infecções por HIV / Infecções por Papillomavirus Tipo de estudo: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Doenças do Ânus / Neoplasias do Ânus / Infecções por HIV / Infecções por Papillomavirus Tipo de estudo: Diagnostic_studies / Etiology_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil