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Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
Angelo, Ana Luiza Dias; Angelo, Camila Dias; Torres, Alex José Leite; Ramos, André Maurício Costa; Lima, Márcia; Netto, Eduardo Martins; Brites, Carlos.
Afiliação
  • Angelo, Ana Luiza Dias; Federal University of Bahia. Professor Edgard Santos Hospital. Infectious Diseases Research Unit. Salvador. BR
  • Angelo, Camila Dias; Federal University of Bahia. Professor Edgard Santos Hospital. Infectious Diseases Research Unit. Salvador. BR
  • Torres, Alex José Leite; Federal University of Bahia. Professor Edgard Santos Hospital. Infectious Diseases Research Unit. Salvador. BR
  • Ramos, André Maurício Costa; Federal University of Bahia. Professor Edgard Santos Hospital. Infectious Diseases Research Unit. Salvador. BR
  • Lima, Márcia; Federal University of Bahia. Professor Edgard Santos Hospital. Hematology Service. Salvador. BR
  • Netto, Eduardo Martins; Federal University of Bahia. Professor Edgard Santos Hospital. Infectious Diseases Research Unit. Salvador. BR
  • Brites, Carlos; Federal University of Bahia. Professor Edgard Santos Hospital. Infectious Diseases Research Unit. Salvador. BR
Braz. j. infect. dis ; Braz. j. infect. dis;11(5): 466-470, Oct. 2007. graf, tab
Article em En | LILACS | ID: lil-465769
Biblioteca responsável: BR1.1
ABSTRACT
This study evaluated total lymphocyte count (TLC) as a substitute marker for CD4+ cell counts to identify patients who need prophylaxis against opportunistic infection (CD4 < 200 cells/mm³) and patients with CD4 < 350 cells/mm³ (Brazilian threshold value of CD4 count to define AIDS). We evaluated TLC and CD4+ cells count of 1,174 HIV-infected patients, in Salvador, Brazil, from May 2003 to September 2004. CD4+ cell counts were performed by flow cytometry, and TLC was measured with an automated hematological counter. The mean CD4 count was 430 cells/mm³ (range 4 to 2,531 cells/mm³). Mean TLC was 1,900 cells/mm³ (range 300 to 6,200 cells/mm³). Using a threshold value of 1,000 cells/mm³ for TLC, the positive predictive value (PPV) was 77 percent for CD4 < 200 cells/mm³, but the sensitivity was only 29 percent, while the negative predictive value (NPV) was 88 percent, with 98 percent specificity. Similar findings were observed for CD4 count < 350. Using the same threshold value of 1,000 cells/mm³ for TLC, sensitivity was 14 percent, and specificity 99 percent (PPV= 94 percent; NPV=62 percent). In 70/1,510 (5 percent) of the samples the sum of CD4 and CD8 cell counts was greater than the TLC and in 27 percent (419/1,510) this sum was below 65 percent of the TLC. TLC has a high specificity to identify patients for prophylaxis, but a quite low sensitivity. It is not useful as an alternative to CD4+ T-cell counts as a marker in HIV-infected patients.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções por HIV / Contagem de Linfócitos Tipo de estudo: Diagnostic_studies / Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Infecções por HIV / Contagem de Linfócitos Tipo de estudo: Diagnostic_studies / Evaluation_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Braz. j. infect. dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil