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Central giant cell granuloma of the jaws and giant cell tumor of long bones: an immunohistochemical comparative study
Aragão, Maria do Socorro; Piva, Marta Rabello; Nonaka, Cassiano Francisco Weege; Freitas, Roseana de Almeida; Souza, Lélia Batista de; Pinto, Leão Pereira.
Afiliação
  • Aragão, Maria do Socorro; Federal University of Paraiba. School of Dentistry. Department of Clinic and Social Dentistry. João Pessoa. BR
  • Piva, Marta Rabello; Federal University of Sergipe. School of Dentistry. Department of Oral Pathology. Aracaju. BR
  • Nonaka, Cassiano Francisco Weege; Federal University of Rio Grande do Norte. School of Dentistry. Department of Oral Pathology. Natal. BR
  • Freitas, Roseana de Almeida; Federal University of Rio Grande do Norte. School of Dentistry. Departament of Oral Pathology. Natal. BR
  • Souza, Lélia Batista de; Federal University of Rio Grande do Norte. School of Dentistry. Department of Oral Pathology. Natal. BR
  • Pinto, Leão Pereira; Federal University of Rio Grande do Norte. School of Dentistry. Department of Oral Pathology. Natal. BR
J. appl. oral sci ; J. appl. oral sci;15(4): 310-316, July-Aug. 2007. ilus, tab
Article em En | LILACS | ID: lil-463684
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVE:

This study investigated whether some components of the extracellular matrix and CD68 expression may drive the differences between the central giant cell granuloma (CGCG) of the jaws and giant cell tumor (GCT) of long bones, which present distinct evolution and clinical behavior. MATERIAL AND

METHODS:

Eight cases of CGCG and 7 cases of GCT were selected and immunohistochemically analyzed to verify the pattern of expression of CD68, tenascin (Tn) and fibronectin (Fn).

RESULTS:

A large number of the mononuclear cells and multinucleated giant cells CD68+ was observed in both of the studied lesions, indicating histiocyte/ macrophage origin. Seven cases of CGCG of the jaws showed intense staining of Fn, with uniform distribution predominantly. In all 7 cases of GCT of long bones the Fn displayed intense expression, with distribution pattern varying from uniform to reticulate/fibrillar. Six cases of CGCG were intensively stained by Tn, presenting focal expression in half of specimens, and reticulate/ fibrillar pattern of expression in 4 cases. All cases of GCT of the long bones presented intense expression of Tn, uniform distribution, and reticulate/fibrillar pattern of expression in four cases.

CONCLUSIONS:

The immunoexpression of CD68 in mononuclear cells and multinucleated giant cells and staining patterns of Fn and Tn were similar in both entities. These findings indicate that these proteins could not be used to explain the differences between the CGCG of the jaws and GCT of the long bones.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: J. appl. oral sci Assunto da revista: ODONTOLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Idioma: En Revista: J. appl. oral sci Assunto da revista: ODONTOLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil