Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue / Association between glutathione peroxidase levels and clinical manifestations of dengue
Rev. méd. Chile
; 135(6): 743-750, jun. 2007. tab
Article
em Es
| LILACS
| ID: lil-459577
Biblioteca responsável:
BR1.1
ABSTRACT
Background:
Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases.Aim:
To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue. Patients andMethods:
Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up.Results:
Mean GP values were 1198 U/L (95 percent confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L.Conclusions:
GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Estresse Oxidativo
/
Dengue
/
Glutationa Peroxidase
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Colombia
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2007
Tipo de documento:
Article
/
Project document
País de afiliação:
Colômbia
País de publicação:
Chile