A microsatellite study of bovine solute carrier family 11 a1 (Slc11a1) gene diversity in Mexico in relation to bovine tuberculosis
Genet. mol. biol
; Genet. mol. biol;29(3): 503-507, 2006. tab
Article
em En
| LILACS
| ID: lil-450290
Biblioteca responsável:
BR26.1
ABSTRACT
Bovine tuberculosis, caused by Mycobacterium bovis, is a disease of socio-economic and public health importance and of significance to international trade regulation. Allelic variants of several genes have been implicated in the genetic susceptibility to tuberculosis in some human populations, but little is known in cattle. We surveyed 34 European, 18 Asian, 20 Creole and 23 hybrid bovines for polymorphisms of the bovine solute carrier family 11 a1(Slc11a1) gene, formerly known as natural resistance associated macrophage protein (Nramp1), gene by typing the cattle using two microsatellite loci closely linked to this gene. The microsatellites used were 311-22, located at the 3' untranslated region (3' UTR) of the Slc11a1 gene, and ARO28 situated about 0.6 cM upstream of the same gene Based on allele size in base pairs (bp) we determined five 311-223 locus variants (221, 223, 225, 227 and 229 bp) and 12 ARO28 loci. There was marked diversity and a very high level of heterozygosity in most of the cattle surveyed except the Europeans bovines and especially Holsteins in relation to the 3' UTR microsatellite locus.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Bovinos
/
Regiões não Traduzidas
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Mycobacterium bovis
Limite:
Animals
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Genet. mol. biol
Assunto da revista:
GENETICA
Ano de publicação:
2006
Tipo de documento:
Article
/
Project document
País de afiliação:
México
País de publicação:
Brasil