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Epigenetic targets in the diagnosis and treatment of prostate cancer
Manoharan, Murugesan; Ramachandran, Kavitha; Soloway, Mark S; Singal, Rakesh.
Afiliação
  • Manoharan, Murugesan; University of Miami. Miller School of Medicine. Department of Urology. Miami. US
  • Ramachandran, Kavitha; University of Miami. Miller School of Medicine. Sylvester Comprehensive and Cancer Center. Miami. US
  • Soloway, Mark S; University of Miami. Miller School of Medicine. Department of Urology. Miami. US
  • Singal, Rakesh; University of Miami. Miller School of Medicine. Sylvester Comprehensive and Cancer Center. Miami. US
Int. braz. j. urol ; 33(1): 11-18, Jan.-Feb. 2007. tab
Article em En | LILACS | ID: lil-447461
Biblioteca responsável: BR1.1
ABSTRACT
Prostate cancer (PC) is one of leading cause of cancer related deaths in men. Various aspects of cancer epigenetics are rapidly evolving and the role of 2 major epigenetic changes including DNA methylation and histone modifications in prostate cancer is being studied widely. The epigenetic changes are early event in the cancer development and are reversible. Novel epigenetic markers are being studied, which have the potential as sensitive diagnostic and prognostic marker. Variety of drugs targeting epigenetic changes are being studied, which can be effective individually or in combination with other conventional drugs in PC treatment. In this review, we discuss epigenetic changes associated with PC and their potential diagnostic and therapeutic applications including future areas of research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias da Próstata / Histonas / Metilação de DNA / Epigênese Genética Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans / Male Idioma: En Revista: Int. braz. j. urol Assunto da revista: UROLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Neoplasias da Próstata / Histonas / Metilação de DNA / Epigênese Genética Tipo de estudo: Clinical_trials / Diagnostic_studies / Prognostic_studies Limite: Humans / Male Idioma: En Revista: Int. braz. j. urol Assunto da revista: UROLOGIA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Brasil