A computer program for single-injection tracer clearance from one, two, or many blood samples
Rev. med. nucl. Alasbimn j
; 8(32)apr. 2006. tab, graf
Article
em En
| LILACS
| ID: lil-444092
Biblioteca responsável:
CL1.1
ABSTRACT
A computer program based on a Bayesian statistical model has been developed for calculating tracer clearance from any number of plasma samples drawn at arbitrary time intervals. Bayesian prior parameters were calculated from clinical data for Tc99m-MAG3, Tc99m-EC, I131-OIH, Tc99m-DTPA, and Yb169-DTPA and then used to calculate clearance from prospective data. Clearance estimates using only one or two plasma samples were found to closely approximate the results of using multiple samples. When only one or a few samples are available, the program supplements the observed data by a Bayesian prior probability distribution (based on prior clinical measurements) to achieve agreement with multisample clearance. When many points are available, the observed data overwhelm the prior probability, and results approach those of conventional curve fitting but with less sensitivity to bad data points and less risk of fitting failure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Simulação por Computador
/
Teorema de Bayes
/
Compostos Radiofarmacêuticos
/
Rim
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Rev. med. nucl. Alasbimn j
Assunto da revista:
MEDICINA NUCLEAR
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Chile