Prospective randomized controlled trial comparing three different ways of anesthesia in transrectal ultrasound-guided prostate biopsy
Int. braz. j. urol
; 32(2): 172-180, Mar.-Apr. 2006.
Article
em En
| LILACS
| ID: lil-429015
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To make an objective controlled comparison of pain tolerance in transrectal ultrasound-guided prostatic biopsy using intrarectal topic anesthesia, injectable periprostatic anesthesia, or low-dose intravenous sedation. MATERIALS ANDMETHODS:
One hundred and sixty patients were randomized into 4 groups group I, intrarectal application of 2 percent lidocaine gel; group II, periprostatic anesthesia; group III, intravenous injection of midazolam and meperidine; and group IV, control, patients to whom no sedation or analgesic was given. Pain was evaluated using an analogue pain scale graded from 0 to 5. Acceptance of a repetition biopsy, the side effects of the drugs and complications were also evaluated.RESULTS:
18/20 (90 percent) and 6/20 (30 percent) patients reported strong or unbearable pain in the group submitted to conventional biopsy and topical anesthesia (p = 0.23, chi-square = 1.41); whereas those submitted to periprostatic blockade and sedation, severe pain occurred in only 2/60 (3 percent) patients (p < 0.001, chi-square = 40.19) and 3/60 (5 percent) patients (p < 0.001, chi-square = 33.34). Acceptance of repetition of the biopsy was present in only 45 percent of the patients submitted to conventional biopsy, 60 percent of those that were given topical anesthesia (p = 0.52, chi-square = 0.4), compared to 100 percent of those submitted to periprostatic anesthesia (p < 0.01, chi-square = 15.17), and 95 percent of those who were sedated (p < 0.001, chi-square = 25.97 percent).CONCLUSIONS:
Transrectal ultrasound-guided prostatic biopsy is an uncomfortable experience; however application of periprostatic blockade and intravenous analgesia are associated to higher tolerance of the exam and patient comfort. Low dose sedation by association of intravenous meperidine and midazolam is an emerging and safe outpatient option.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Próstata
/
Medição da Dor
/
Anestesia
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
En
Revista:
Int. braz. j. urol
Assunto da revista:
UROLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil