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Excellent response to interferon therapy in a patient with hypereosinophilic syndrome and elevated serum immunoglobulin E levels
Acaba, L; Mangual, A; Vélez García, E.
Afiliação
  • Acaba, L; University of Puerto Rico. School of Medicine. Hematology-Medical Oncology Section. San Juan. PR
  • Mangual, A; University of Puerto Rico. School of Medicine. Hematology-Medical Oncology Section. San Juan. PR
  • Vélez García, E; University of Puerto Rico. School of Medicine. Hematology-Medical Oncology Section. San Juan. PR
Bol. Asoc. Méd. P. R ; Bol. Asoc. Méd. P. R;92(4/8): 59-62, Apr.-Aug. 2000.
Article em En | LILACS | ID: lil-411272
Biblioteca responsável: BR1.1
ABSTRACT
The hypereosinophilic syndrome (HES) is a heterogeneous disease characterized by sustained eosinophilia for a period of at least six months with evidence of organ involvement. Its manifestations range from a benign disorder not requiring any therapy to an aggressive, malignant variety refractory to common treatments. Diverse therapies have been used, including steroids, hydroxyurea, and chemotherapy, with variable responses. Recently alpha-interferon therapy has been shown effective in this disorder. Of the various prognostic factors, elevated serum immunoglobulin E (IgE) levels is considered among the most favorable, with most patients presenting with a [quot ]benign[quot ] disorder, not requiring therapy. We describe a patient presenting with an aggressive variant of HES despite having elevated IgE levels. The patient had a dramatic and lasting response to alpha-interferon
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Interferon-alfa / Síndrome Hipereosinofílica / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Bol. Asoc. Méd. P. R Assunto da revista: MEDICINA Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Porto Rico País de publicação: Porto Rico
Buscar no Google
Adicionar na Minha BVS
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Interferon-alfa / Síndrome Hipereosinofílica / Antineoplásicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Humans / Male Idioma: En Revista: Bol. Asoc. Méd. P. R Assunto da revista: MEDICINA Ano de publicação: 2000 Tipo de documento: Article País de afiliação: Porto Rico País de publicação: Porto Rico