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Antioxidant and antimicrobial activities of Bauhinia racemosa L. stem bark
Kumar, R. S; Sivakumar, T; Sunderam, R. S; Gupta, M; Mazumdar, U. K; Gomathi, P; Rajeshwar, Y; Saravanan, S; Kumar, M. S; Murugesh, K; Kumar, K. A.
Afiliação
  • Kumar, R. S; J.K.K. Natarajah College of Pharmacy. Department of Pharmaceutics and Pharmacology. Tamilnadu. IN
  • Sivakumar, T; J.K.K Natarajah College of Pharmacy. Department of Pharmaceutics and Pharmacology. Tamilnadu. IN
  • Sunderam, R. S; J.K.K Natarajah College of Pharmacy. Department of Pharmaceutics and Pharmacology. Tamilnadu. IN
  • Gupta, M; Jadavpur University. Department of Pharmaceutical Technology. Division of Pharmacology and Pharmaceutical Chemistry. Kolkata. IN
  • Mazumdar, U. K; Jadavpur University. Department of Pharmaceutical Technology. Division of Pharmacology and Pharmaceutical Chemistry. Kolkata. IN
  • Gomathi, P; Jadavpur University. Department of Pharmaceutical Technology. Division of Pharmacology and Pharmaceutical Chemistry. Kolkata. IN
  • Rajeshwar, Y; Jadavpur University. Department of Pharmaceutical Technology. Division of Pharmacology and Pharmaceutical Chemistry. Kolkata. IN
  • Saravanan, S; Jadavpur University. Department of Pharmaceutical Technology. Division of Pharmacology and Pharmaceutical Chemistry. Kolkata. IN
  • Kumar, M. S; Jadavpur University. Department of Pharmaceutical Technology. Division of Pharmacology and Pharmaceutical Chemistry. Kolkata. IN
  • Murugesh, K; Jadavpur University. Department of Pharmaceutical Technology. Division of Pharmacology and Pharmaceutical Chemistry. Kolkata. IN
  • Kumar, K. A; Sri Ramakrishna Institute of Paramedical Sciences. Department of Pharmacology. Coimbatore. IN
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;38(7)July 2005. tab, graf
Article em En | LILACS | ID: lil-403856
Biblioteca responsável: BR1.1
RESUMO
The present study was carried out to evaluate the antioxidant and antimicrobial activities of a methanol extract of Bauhinia racemosa (MEBR) (Caesalpiniaceae) stem bark in various systems. 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) radical, superoxide anion radical, nitric oxide radical, and hydroxyl radical scavenging assays were carried out to evaluate the antioxidant potential of the extract. The antioxidant activity of the methanol extract increased in a concentration-dependent manner. About 50, 100, 250, and 500 æg MEBR inhibited the peroxidation of a linoleic acid emulsion by 62.43, 67.21, 71.04, and 76.83 percent, respectively. Similarly, the effect of MEBR on reducing power increased in a concentration-dependent manner. In DPPH radical scavenging assays the IC50 value of the extract was 152.29 æg/ml. MEBR inhibited the nitric oxide radicals generated from sodium nitroprusside with an IC50 of 78.34 æg/ml, as opposed to 20.4 æg/ml for curcumin. Moreover, MEBR scavenged the superoxide generated by the PMS/NADH-NBT system. MEBR also inhibited the hydroxyl radical generated by Fenton's reaction, with an IC50 value of more than 1000 æg/ml, as compared to 5 æg/ml for catechin. The amounts of total phenolic compounds were also determined and 64.7 æg pyrocatechol phenol equivalents were detected in MEBR (1 mg). The antimicrobial activities of MEBR were determined by disc diffusion with five Gram-positive, four Gram-negative and four fungal species. MEBR showed broad-spectrum antimicrobial activity against all tested microorganisms. The results obtained in the present study indicate that MEBR can be a potential source of natural antioxidant and antimicrobial agents.
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Bauhinia / Fungos Mitospóricos / Bactérias Gram-Positivas / Antibacterianos / Antifúngicos / Antioxidantes Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Bauhinia / Fungos Mitospóricos / Bactérias Gram-Positivas / Antibacterianos / Antifúngicos / Antioxidantes Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Índia País de publicação: Brasil