Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase
Mem. Inst. Oswaldo Cruz
; 100(supl.1): 83-91, Mar. 2005. ilus, graf
Article
em En
| LILACS
| ID: lil-402180
Biblioteca responsável:
BR1.1
RESUMO
Platelet-activating factor (PAF) is one of the most potent lipid mediators involved in inflammatory events. The acetyl group at the sn-2 position of its glycerol backbone is essential for its biological activity. Deacetylation induces the formation of the inactive metabolite lyso-PAF. This deacetylation reaction is catalyzed by PAF-acetylhydrolase (PAF-AH), a calcium independent phospholipase A2 that also degrades a family of PAF-like oxidized phospholipids with short sn-2 residues. Biochemical and enzymological evaluations revealed that at least three types of PAF-AH exist in mammals, namely the intracellular types I and II and a plasma type. Many observations indicate that plasma PAF AH terminates signals by PAF and oxidized PAF-like lipids and thereby regulates inflammatory responses. In this review, we will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Plaquetas
/
Fator de Ativação de Plaquetas
/
Inflamação
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Brasil
/
Estados Unidos
País de publicação:
Brasil