Edad materna y defectos del tubo neural: evidencia para un efecto mayor en espina bífida que anencefalia / Influence of maternal age on the risk for neural tube defects, a meta analysis
Rev. méd. Chile
; 133(1): 62-70, ene. 2005. tab
Article
em Es
| LILACS
| ID: lil-398017
Biblioteca responsável:
CL12.1
ABSTRACT
Background:
Recent evidence from birth order data suggest that maternal factors can differently influence anencephaly and spina bifida.Aim:
To study the influence of maternal age on the risk for neural tube defects. Material andmethods:
A meta-analysis of published data on neural tube defects (NTDs) was carried out to determine whether there is an increased risk to have a child with NTDs for younger and older mothers and if this risk differs depending on the type of NTD. All data available with information regarding the frequency of live births and NTDs cases by maternal age (five- or ten-year intervals) were included in the analysis. Effect sizes calculations were performed.Results:
The analysis supports the hypothesis that there is an increased risk of having an offspring with NTDs for mothers 40 years of age or older. However, this effect is stronger for spina bifida than for anencephaly. There is also evidence that mothers 19 years old or younger have a higher risk for having a child with spina bifida.Conclusions:
Maternal age influences the risk of having an offspring with neural tube defects.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Idade Materna
/
Defeitos do Tubo Neural
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Adolescent
/
Female
/
Humans
/
Pregnancy
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2005
Tipo de documento:
Article
/
Project document
País de afiliação:
Chile
/
Estados Unidos
País de publicação:
Chile