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Effect of propolis extract on guines pig lung mast cell
Orsi, R. O; Sforcin, J. M; Funari, S. R. C; Gomes, J. C.
Afiliação
  • Orsi, R. O; Universidade Estadual Paulista. School of Veterinary Medicine and Animal Husbrandy. Department of Animal Production. Botucatu. BR
  • Sforcin, J. M; Universidade Estadual Paulista. Institute of Biosciences. Department of Microbiology and Immunology. Botucatu. BR
  • Funari, S. R. C; Universidade Estadual Paulista. School of Veterinary Medicine and Animal Husbrandy. Department of Animal Production. Botucatu. BR
  • Gomes, J. C; Universidade Estadual Paulista. Institute of Biosciences. Department of Pharmacology. Botucatu. BR
J. venom. anim. toxins incl. trop. dis ; J. venom. anim. toxins incl. trop. dis;11(1): 76-83, jan.-abr. 2005. graf
Article em En | LILACS, VETINDEX | ID: lil-396702
Biblioteca responsável: BR68.1
RESUMO
The direct effect of ethanolic extract of propolis on guinea pig lung cell suspension containing mast cells, as well as its influence on the histamine release induced by antigen (ovoalbumin 10 mug/ml) and ionophore A 23187 (3 muM) were investigated. Propolis ethanolic extract (300 mug/ml) increased the histamine release in guinea pig lung suspension containing mast cells by a cytotoxic effect. Lower concentrations of propolis had no effect on histamine release. Our results demonstrated that propolis (3, 10, 30, and 100 mug/ml) shows no significant effect on the histamine release induced by ionophore and antigen. Based on these results, we suggest that propolis could directly activate mast cells, promoting inflammatory mediators release by cytotoxic mechanisms, what could be related to allergic processes in propolis sensitive people.(AU)
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Assunto principal: Própole / Histamina / Mastócitos Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo
Adicionar na Minha BVS
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / VETINDEX Assunto principal: Própole / Histamina / Mastócitos Idioma: En Revista: J. venom. anim. toxins incl. trop. dis Assunto da revista: TOXICOLOGIA Ano de publicação: 2005 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil