Biodistribution studies of bee venom and spider toxin using radiotracers
J. venom. anim. toxins incl. trop. dis
; J. venom. anim. toxins incl. trop. dis;11(1): 39-50, jan.-abr. 2005. tab, graf
Article
em En
| LILACS, SES-SP, VETINDEX
| ID: lil-396699
Biblioteca responsável:
BR68.1
RESUMO
The use of radiotracers allows the understanding of the bioavailability process, biodistribution, and kinetics of any molecule labelled with an isotope, which does not alter the molecule's biological properties. In this work, technetium-99m and iodine-125 were chosen as radiotracers for biodistribution studies in mice using bee (Apis mellifera) venom and a toxin (PnTX2-6) from the Brazilian "armed" spider (Phoneutria nigriventer) venom. Incorporated radioactivity was measured in the blood, brain, heart, lung, liver, kidney, adrenal gland, spleen, stomach, testicle, intestine, muscle, and thyroid gland. Results provided the blood kinetic parameter, and different organs distribution rates.(AU)
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
/
SES-SP
/
VETINDEX
Assunto principal:
Venenos de Aranha
/
Venenos de Abelha
/
Abelhas
Limite:
Animals
Idioma:
En
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
TOXICOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil