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The effects of aging on biceps brachii muscle fibers: a morphometrical study from biopsies and autopsies
Mattiello-Sverzut, Ana Cláudia; Chimelli, Leila; Moura, Maria Silvia de Assis; Teixeira, Silvia; Oliveira, José Alberto Mello de.
Afiliação
  • Mattiello-Sverzut, Ana Cláudia; University of Säo Paulo. School of Medicine of Ribeiräo Preto. Department of Pathology. Ribeiräo Preto. BR
  • Chimelli, Leila; Federal University of Rio de Janeiro. University Hospital. Pathology Division. BR
  • Moura, Maria Silvia de Assis; Federal University of Säo Carlos. Department of Statistics. Säo Carlos. BR
  • Teixeira, Silvia; University of Säo Paulo. School of Medicine of Ribeiräo Preto. Department of Pathology. Ribeiräo Preto. BR
  • Oliveira, José Alberto Mello de; University of Säo Paulo. School of Medicine of Ribeiräo Preto. Ribeiräo Preto. BR
Arq. neuropsiquiatr ; Arq. neuropsiquiatr;61(3A): 555-560, Sept. 2003. ilus, tab, graf
Article em En | LILACS | ID: lil-345767
Biblioteca responsável: BR1.1
RESUMO

OBJECTIVES:

In order to study the morphology and size of muscle fibers, cross sections of biceps brachii samples from autopsies, up to 9 hours after death, and biopsies of 72 subjects were compared. The subjects aged 13 to 84 years in both sexes.

METHODS:

The samples obtained from autopsies (n=47) were from subjects with sudden death, or who died after acute disease without evidence of neuromuscular involvement. The biopsies (n=25) were from patients with symptoms suggestive of inflammatory or metabolic myopathy, not confirmed morphologically. The lesser diameter of muscle fibers was measured using the ATPase reaction.

RESULTS:

Morphological analysis showed that aging changes were present from the sixth decade in autopsies, and consisted of atrophy and/or type-grouping. The statistical models adjusted for females in both autopsies and biopsies were linear straight with no variation in fiber size with increasing age. The models adjusted for males in both groups were quadratic, indicating that age influenced the size of different type fibers. In males type 2 were larger than type 1 fibers, and than fibers in females.

CONCLUSIONS:

These values might be useful as controls, helping interpretation of changes in fiber size in samples obtained from biopsies and autopsies
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Envelhecimento / Fibras Musculares Esqueléticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged80 / Female / Humans / Male Idioma: En Revista: Arq. neuropsiquiatr Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Envelhecimento / Fibras Musculares Esqueléticas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged80 / Female / Humans / Male Idioma: En Revista: Arq. neuropsiquiatr Assunto da revista: NEUROLOGIA / PSIQUIATRIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil