Antibiotic susceptibility of Clostridium difficile isolates from adult patients at two Jamaican hospitals. Clinical and epidemiological implications
West Indian med. j
; West Indian med. j;50(1): 50-54, Mar. 2001.
Article
em En
| LILACS
| ID: lil-333413
Biblioteca responsável:
BR1.1
ABSTRACT
The susceptibility of 39 toxin producing Clostridium difficile isolates from stools of hospitalized patients was determined, by disc diffusion, to six antibiotics. All but one isolate (toxin A negative) produced toxin A and toxin B. A wide variation in susceptibility to clindamycin, tetracycline and chloramphenicol was noted. Erythromycin and cotrimoxazole showed a clear-cut discrimination in resistance and susceptibility, while all isolates were sensitive to vancomycin. Erythromycin sensitive isolates demonstrated a significant association with diarrhoea (60.9, 14/23, p < 0.001). These strains were predominantly found at the University Hospital of the West Indies (UHWI, 94.1, 16/17). Strains resistant to erythromycin and clindamycin together were commonly found at the National Chest Hospital (NCH, 68.2, 15/22). All erythromycin sensitive strains found at the NCH were from patients transferred to that hospital. These findings suggest that there is a common strain of C difficile (erythromycin resistant) at the NCH different from that found at the UHWI; the resistant pattern seen with isolates from the NCH was typical of toxigenic serogroup C strain and could be typed by the the disc diffusion method. Patients at the NCH who were colonized with either of the two strains of C difficile were likely to get diarrhoea, once there was suppression of the normal microflora by antibiotics and colonic overgrowth with C difficile.
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Enterocolite Pseudomembranosa
/
Testes de Sensibilidade Microbiana
/
Clostridioides difficile
/
Diarreia
/
Antibacterianos
Limite:
Adolescent
/
Adult
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
West Indian med. j
Assunto da revista:
MEDICINA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Jamaica
País de publicação:
Jamaica