Ion movements in cell death: from protection to exection
Biol. Res
; 35(2): 209-214, 2002.
Article
em En
| LILACS
| ID: lil-323343
Biblioteca responsável:
BR1.1
ABSTRACT
Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+] and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+] and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including channels, pumps and carriers
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Morte Celular
/
Canais Iônicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biol. Res
Assunto da revista:
BIOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
/
Project document
País de afiliação:
Chile
País de publicação:
Chile