Hepatitis B vaccine--proposal for a standardized assessment of immune response
Rev. Inst. Med. Trop. Säo Paulo
; Rev. Inst. Med. Trop. Säo Paulo;34(2): 137-140, Mar.-Apr. 1992.
Article
em En
| LILACS
| ID: lil-320621
Biblioteca responsável:
BR1.1
ABSTRACT
The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intramuscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzyme immunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Vacinas contra Hepatite B
/
Anticorpos Anti-Hepatite B
Limite:
Adolescent
/
Adult
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Female
/
Humans
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Male
Idioma:
En
Revista:
Rev. Inst. Med. Trop. Säo Paulo
Assunto da revista:
MEDICINA TROPICAL
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil