Vasorelaxant effects of the potassium channel opener SR 47063 on the isolated human saphenous vein and rat aorta
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;33(8): 961-6, Aug. 2000. tab, graf
Article
em En
| LILACS
| ID: lil-265854
Biblioteca responsável:
BR1.1
ABSTRACT
The vasorelaxant effects of SR 47063 (4-(2-cyanimino-1,2-dihydropyrid-1-yl)-2,2-dimethyl-6-nitrochromene), a new K+-channel opener structurally related to levcromakalim, were examined in isolated human saphenous vein (HSV) and rat aorta (RA). HSV or RA rings were precontracted with either KCl or noradrenaline and cumulative relaxant concentration-response curves were obtained for SR 47063 (0.1 nM to 1 µM) in the presence or absence of 3 µM glibenclamide. SR 47063 potently relaxed HSV and RA precontracted with 20 mM (but not 60 mM) KCl or 10 µM noradrenaline in a concentration-dependent manner, showing slightly greater activity in the aorta. The potency of the effect of SR 47063 on HSV and RA was 12- and 58-fold greater, respectively, than that reported for the structurally related K+-channel opener levcromakalim. The vasorelaxant action of SR 47063 in both blood vessels was strongly inhibited by 3 µM glibenclamide, consistent with a mechanism of action involving ATP-dependent K+-channels
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Aorta
/
Veia Safena
/
Vasodilatadores
/
Cromanos
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil