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Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de streptococcus pyogenes y su asociación con la clínica / Detection of pyrogenic exotoxin SpeA, SpeB and SpeC genes in chilean streptococci isolates and their association with clinical manifestations
Ulloa F., María Teresa; Giglio Maira, María Soledad; Porte T., Lorena; Santa Cruz A., Adriana; Mcnab M., Paul; Fica C., Alberto; Pinto Claude, María Eugenia; Kawaguchi G., Keyko; Carmi K., Alejandra.
Afiliação
  • Ulloa F., María Teresa; Universidad de Chile. Facultad de Medicina. ICBM. Programa de Microbiología y Micología.
  • Giglio Maira, María Soledad; Universidad de Chile. Facultad de Medicina. ICBM. Programa de Microbiología y Micología.
  • Porte T., Lorena; Universidad de Chile. Facultad de Medicina. ICBM. Programa de Microbiología y Micología.
  • Santa Cruz A., Adriana; Universidad de Chile. Facultad de Medicina. ICBM. Programa de Microbiología y Micología.
  • Mcnab M., Paul; Universidad de Chile. Facultad de Medicina. ICBM. Programa de Microbiología y Micología.
  • Fica C., Alberto; Universidad de Chile. Facultad de Medicina. ICBM. Programa de Microbiología y Micología.
  • Pinto Claude, María Eugenia; Universidad de Chile. Facultad de Medicina. ICBM. Programa de Microbiología y Micología.
  • Kawaguchi G., Keyko; s.af
  • Carmi K., Alejandra; s.af
Rev. méd. Chile ; 128(1): 27-34, ene. 2000. tab, graf
Article em Es | LILACS | ID: lil-258084
Biblioteca responsável: CL1.1
ABSTRACT

Background:

The virulence of Streptococcus pyogenes is determined by a variety of structural molecules, toxins and complex enzymes. Pyrogenic exotoxins cause fever, erythematous reactions, cytotoxic and immunological effects.

Aim:

To assess the frequency of speA, speB and speC genes in Chilean Streptococcus pyogenes strains and their association with the invasiveness of infections. Material and

methods:

The genes for pyrogenic exotoxins SpeA, SpeB and SpeC were determined by polymerase chain reactions in 114 strains of group A Streptococcus pyogenes isolated from Chilean patients with invasive or non invasive infections.

Results:

The gene for SpeA was present in 30.7 percent of isolates, the gene for SpeB was present in 69.3 percent and the gen for SpeC in 44.7 percent of isolates. The gene for SpeA was present in 20 of 33 invasive infections and in 15 of 81 non invasive infections (p <0.0001). On the contrary, the gene for SpeC was present in 11 of 33 invasive infections and in 41 of 81 non invasive infections (p <0.05). The frequency of speB was similar in invasive and non invasive infections.

Conclusions:

There is a clear relationship between the presence of SpeA genes and the severity of infections caused by Streptococcus pyogenes
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Streptococcus pyogenes / Técnicas In Vitro Tipo de estudo: Diagnostic_studies / Risk_factors_studies País/Região como assunto: America do sul / Chile Idioma: Es Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2000 Tipo de documento: Article País de publicação: Chile
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Streptococcus pyogenes / Técnicas In Vitro Tipo de estudo: Diagnostic_studies / Risk_factors_studies País/Região como assunto: America do sul / Chile Idioma: Es Revista: Rev. méd. Chile Assunto da revista: MEDICINA Ano de publicação: 2000 Tipo de documento: Article País de publicação: Chile