Manejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente / Multidisciplinary management of hepatic malignant tumors in children: report of 6 cases
Rev. méd. Chile
; 127(11): 1351-8, nov. 1999. ilus, tab
Article
em Es
| LILACS
| ID: lil-257994
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
malignant hepatic tumors (Mht) are rare in children. Among them hepatoblastoma (HB) is the most common.Aim:
to report the results of the multidisciplinary management in 6 consecutive children five HB and one metastatic Wilms tumor (MWT). Patients andmethods:
the mean age of patients was 42 months. All HB patients had elevated serum alfafetoprotein (median 150,000 ng/ml). All patients received preoperative chemotherapy HB patients received carboplatin/doxorrubicin alternating with cisplatin, and the MWT patient, vincristine alone. Surgery included two formal right and two formal left hepatectomies, one extensive central resection with partial left segmentectomy, and one lateral segmentectomy. Extracorporeal circulation was used in the child with atrial involvement. All patients received postoperative chemotherapy.Results:
all tumors had variable regresion on preoperative chemotherapy. Complete resection with negative margins was achieved in all patients. The degree of tumor necrosis on histology ranged from 60 percent to 90 percent. Alfafetoprotein levels fell to under 10 ng/ml in all HB cases, one to three months after surgery. All patients survive free of disease at a median follow up of 19 months.Conclusion:
a multidisciplinary approach including the well timed used of chemotherapy and surgery is highly effective in the management of pediatric malignant tumors
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Segunda Neoplasia Primária
/
Hepatoblastoma
/
Neoplasias Hepáticas
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
1999
Tipo de documento:
Article
País de publicação:
Chile