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Bioavailability of etoposide after oral administration of the solution marketed for intravenous use: Therapeutic and pharmacoeconomic perspectives
Aguilar Ponce, José Luis; Flores Pizaco, Yolanda; Pérez Urizar, José; Castañeda Hernández, Gilberto; Zinser Sierra, Juan W; Dueñas González, Alfonso; Calderón Flores, Ernesto; Segura Pacheco, Blanca Angélica; de la Garza Salazar, Jaime.
Afiliação
  • Aguilar Ponce, José Luis; s.af
  • Flores Pizaco, Yolanda; s.af
  • Pérez Urizar, José; s.af
  • Castañeda Hernández, Gilberto; s.af
  • Zinser Sierra, Juan W; s.af
  • Dueñas González, Alfonso; s.af
  • Calderón Flores, Ernesto; s.af
  • Segura Pacheco, Blanca Angélica; s.af
  • de la Garza Salazar, Jaime; s.af
Arch. med. res ; Arch. med. res;30(3): 212-5, mayo-jun. 1999. tab, graf
Article em En | LILACS | ID: lil-256650
Biblioteca responsável: MX1.1
RESUMO
Background. Oral etoposide administration is a suitable alternative to the intravenous route; therefore, commercial capsules have been developed. Before these capsules were available in Mexico, we studied drug bioavailability after oral administration of the intravenous etoposide solution (IVES). Methods. Eight adult cancer patients received a 50-mg oral etoposide dose as IVES and blood samples were collected over a period of 24 h. plasma etoposide concentration was determined by high-performance liquid chromatography, plasma concentration against time curves were constructed, and biovailability parameters were calculated. Results. Oral IVES yielded an adequate bioavailability profile because Cmax was 2.38 ñ 0.30 µg/mL, AUC was 12.87 ñ 2.02 µg/mL and half-life was 6.72 ñ 0.97 h. Conclusions. Considering that the pharmacokinetic aim is to maintain plasm concentrations between 0.5 and 1.0 µg/mL for several hours while avioding high concentrations, i.e., of 10 µg/mL or higher, oral administration of 50-mg etoposide as IVES appears to be a suitable dosing option. In addition, oral IVES is considerably less expensive than intravenous administration in terms of both drug presentation and administration
Assuntos
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Farmacoeconomia / Etoposídeo / Injeções Intravenosas / Antineoplásicos Fitogênicos Tipo de estudo: Health_economic_evaluation Limite: Female / Humans / Male Idioma: En Revista: Arch. med. res Assunto da revista: MEDICINA Ano de publicação: 1999 Tipo de documento: Article País de publicação: México
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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Farmacoeconomia / Etoposídeo / Injeções Intravenosas / Antineoplásicos Fitogênicos Tipo de estudo: Health_economic_evaluation Limite: Female / Humans / Male Idioma: En Revista: Arch. med. res Assunto da revista: MEDICINA Ano de publicação: 1999 Tipo de documento: Article País de publicação: México