Thyrotoxic periodic paralysis in mexican mestizo patients: a clinical, biochemical and HLA-Serological study
Arch. med. res
; Arch. med. res;30(1): 74-6, ene.-feb. 1999. tab
Article
em En
| LILACS
| ID: lil-256625
Biblioteca responsável:
MX1.1
RESUMO
Background. Thyrotoxic periodic paralysis (TPP) is characterized by episodes of neuromuscular weakness occurring in the context of hypokalemia and hyperthyroidism and has been predominantly described in Oriental populations. Whereas it is uncommon in Caucasians and Blacks, TPP does occur in individuals of Native American descent. The objective was to analyze the clinical, biochemical, and HLA characteristics of group of Mexican mestizo patients with TPP. Methods. The sample was comprised of 14 men with TPP diagnosed since january 1990, based on one or more episodes of flaccid paralysis, accompanied by hypokalemia and occurring in the context of clinical and biochemical hyperthyroidism. Eight were available HLA testing. Results. Hyperthyroidsm was diagnosed before the development of periodic paralysis in five of the patients, whereas in six it occurred afterward. The severity of paralysis did not correlate with the degree of either hypokalemia or hyperthyroidism. An increased frequency of HLA-DR3 was found in Graves' patients without paralysis but not in those with paralysis, as compared to the general population. Conclusions. TPP is more common than previously thoought in Mexicans, in whom it behaves as in other Native American groups. The lack of HLA-DR3 association in Graves' patients with TPP is interesting, but at the moment has no pathophysiological implications
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Paralisia
/
Tireotoxicose
/
Etnicidade
/
Doença de Graves
/
População Branca
/
Frequência do Gene
/
Antígenos HLA
/
Hipopotassemia
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Humans
/
Male
País/Região como assunto:
Mexico
Idioma:
En
Revista:
Arch. med. res
Assunto da revista:
MEDICINA
Ano de publicação:
1999
Tipo de documento:
Article
País de publicação:
México