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Hepatic regeneration after partial hepatectomy in mice infected with Schistosoma mansoni, at the acute and chronic phases of the disease
Costa, G; Cunha-Melo, J. R; Aguiar, B. G; Gonçalves, S. C; Toppa, N. H; Coelho, P. M. Z.
Afiliação
  • Costa, G; Federal University of Minas Gerais. School of Medicine. Department of Surgery.
  • Cunha-Melo, J. R; Federal University of Minas Gerais. School of Medicine. Department of Surgery.
  • Aguiar, B. G; Federal University of Minas Gerais. School of Medicine. Department of Surgery.
  • Gonçalves, S. C; Federal University of Minas Gerais. School of Medicine. Department of Surgery.
  • Toppa, N. H; Federal University of Minas Gerais. School of Medicine. Department of Pathologic Anatomy.
  • Coelho, P. M. Z; Federal University of Minas Gerais. Institute of Biological Sciences. Department of Parasitology.
Rev. Inst. Med. Trop. Säo Paulo ; Rev. Inst. Med. Trop. Säo Paulo;41(4): 255-8, July-Aug. 1999. tab
Article em En | LILACS | ID: lil-246836
Biblioteca responsável: BR1.1
RESUMO
Outbred male albino mice normal or infected with 30 cercariae of Schistosoma mansoni (LE strain) were submitted to 65 percent hepatectomy during the acute (70 days) and chronic phase (160 days) phases of the disease. A group of the infected animals was treated with 400 mg/kg of oxamniquine during the acute phase before hepatectomy. Non-infected, infected and treated but not hepatectomized animals were kept as controls. Hepatic regeneration was evaluated by incorporation of tritiated thymidine, intraperitoneally injected into non-hepatectomized and hepatectomized animals, 24 hours after surgery. The results showed that removal of 65 percent of the hepatic parenchyma, during the acute phase, led to a statistically significant increase of thymidine incorporation, when compared with the uninfected hepatectomized controls. This phenomenon was not observed at the chronic phase. Treatment with oxamniquine administered during the acute phase led to a decrease in thymidine incorporation rate 160 days after infection (90 days after treatment) and 24 hours after hepatectomy. The data suggest that infection with S. mansoni represents a considerable stimulus for the regenerative capacity of the liver during the acute, but not the chronic phase of disease
Assuntos
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Oxamniquine / Schistosoma mansoni / Esquistossomose mansoni / Hepatectomia / Regeneração Hepática Limite: Animals Idioma: En Revista: Rev. Inst. Med. Trop. Säo Paulo Assunto da revista: MEDICINA TROPICAL Ano de publicação: 1999 Tipo de documento: Article País de publicação: Brasil
Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Oxamniquine / Schistosoma mansoni / Esquistossomose mansoni / Hepatectomia / Regeneração Hepática Limite: Animals Idioma: En Revista: Rev. Inst. Med. Trop. Säo Paulo Assunto da revista: MEDICINA TROPICAL Ano de publicação: 1999 Tipo de documento: Article País de publicação: Brasil