Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
Genet. mol. biol
; Genet. mol. biol;22(1): 17-20, Mar. 1999. tab, ilus
Article
em En
| LILACS
| ID: lil-243512
Biblioteca responsável:
BR1.1
RESUMO
Human peripheral blood lymphocytes from 10 patients with familial adenomatous polyposis (FAP) showed a significantly higher incidence of chromatid breaks when compared to cells from 10 normal individuals, after exposure to bleomycin (BLM) during the G2 phase. However, no significant increase in bleomycin sensitivity was observed in lymphocytes from 10 patients with sporadic adenomatous polyps (AP) vs. 10 normal individuals (P = 0.67). Individuals that exhibited an average number of chromatid breaks per cell higher than 0.80 were considered sensitive to the drug. No control showed susceptibility to BLM, as compared to 3 out of 20 patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Bleomicina
/
Cromátides
/
Polipose Adenomatosa do Colo
/
Antibióticos Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Genet. mol. biol
Assunto da revista:
GENETICA
Ano de publicação:
1999
Tipo de documento:
Article
País de publicação:
Brasil