Actividad de diterpenoides de azorella compacta, llareta, sobre amastigotes de trypanosoma cruzi / Activity of dipernoids isolated from azorella compacta, llareta, on trypanosoma cruzi amastigotes
Bol. chil. parasitol
; 53(1-2): 9-13, ene.-jun. 1998. ilus, tab
Article
em Es
| LILACS
| ID: lil-233091
Biblioteca responsável:
CL1.1
ABSTRACT
The trypanocidad activity against amastigote forms of SPA-14, Tulahuen and G strains and CL Brener clone of Trypanosoma cruzi of diterpenoids isolated from Azorella compacta. Phil. (Llareta), a plant with ethnomedicinal prestige from prespanish age, was investigated. Amastigocidal activity was shown in azorellanol (2), diterpene isolated by first time, with an inhitory concentration 50 (IC) that varied between 60 M (CL Brener clone) and 84 M (SPA-14 strain), and in mulin -11,13 -dien-20-oico acid (5) with IC between 41 µM (G strain) and 87 mM (CL Brener clone). The cytotoxicity levels of both compounds against Hela and Vero cells and macrophages J144 are lower than nifurtimox and similar to gentian violet
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Plantas Medicinais
/
Trypanosoma cruzi
Limite:
Humans
Idioma:
Es
Revista:
Bol. chil. parasitol
Assunto da revista:
ALIMENTOS
/
PARASITOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de publicação:
Chile