Sodium cyanate: from a promising therapeutic agent to a research tool in high altitude physiology
Biol. Res
; 29(2): 167-76, 1996.
Article
em En
| LILACS
| ID: lil-228529
Biblioteca responsável:
BR1.1
RESUMO
Sodium cyanate (NaOCN) first appeared on the biomedical scene as a potential therapeutic agent for sickle-cell disease. Although it did not fulfill its early promise in the clinic, it proved to be useful as a pharmacological tool in physiological research, particularly in the physiology of oxygen transport. NaOCN has been especially valuable in the area of investigation which is reviewed here the study of oxygen transport, both in normoxic and in hypoxic conditions, in experimental models in which NaOCN was used to induce a shift to the left of the oxygen dissociation curve. The classical idea is that a low Hb-O2 affinity is of adaptive value for life at high altitudes but it has been challenged by several pieces of evidence. One of them is the demonstration of increased survival in hypoxic hypoxia of animals with a high Hb-O2 affinity induced by NaOCN. We also discuss the advantages and potentially confounding factors which should be taken into consideration when interpreting results of studies in which the oxygen dissociation curve has been modified by administration of NaOCN
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Hemoglobinas
/
Ventilação Pulmonar
/
Cianatos
/
Desenvolvimento Fetal
/
Eritropoese
/
Altitude
/
Anemia Falciforme
/
Hipóxia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biol. Res
Assunto da revista:
BIOLOGIA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Chile