Smooth muscle cell diversity and the extracellular matrix in a rat model of restenosis
P. R. health sci. j
; P. R. health sci. j;15(3): 187-91, Sept. 1996.
Article
em En
| LILACS
| ID: lil-228510
Biblioteca responsável:
BR1.1
ABSTRACT
Clear differences exist in the incidence and severity of atherosclerotic plaques that arise in different segments of the arterial tree. Aortic homograft transplant experiments in dogs showed that the greater incidence of plaque formation in the abdominal versus the thoracic aorta was due to intrinsic differences in the cell populations in these two segments rather than to hemodynamic factors. What is the basis for SMC diversity within a common vessel wall? Recent lineage analysis studies in the avian and mammalian embryo indicate that two distinct SMC lineages contribute to the formation of the major elastic outflow arteries including the aorta. A mixture of unique SMC types of diverse developmental lineages within a common vessel wall raises new questions about the potential for SMC type-specific responses to growth factors and cytokines involved in human atherosclerosis and restenosis
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Angioplastia Coronária com Balão
/
Doença das Coronárias
/
Modelos Animais de Doenças
/
Matriz Extracelular
/
Músculo Liso Vascular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
P. R. health sci. j
Assunto da revista:
MEDICINA
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Porto Rico