Cardiovascular responses to microinjection of trans -(+)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;31(4): 573-9, Apr. 1998. ilus
Article
em En
| LILACS
| ID: lil-212424
Biblioteca responsável:
BR1.1
ABSTRACT
The changes in mean arterial pressure (MAP) and heart rate (HR) in response to the activation of metabotropic receptors in the nucleus tractus solitarii (NTS) with trans-(+)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-(+)-ACPD) were evaluated in conscious and anesthetized Wistar, male rats weighing 240-260g (N=8). The responses obtained with trans-(+)-ACPD were compared with the responses to L-glutamate (1 nmol/100 nl), since in a previous study we showed that anesthesia converted a pressor response to L-glutamate microinjected into the NTS of conscious rats to a depressor response in the same rats under urethane or chloralose anesthesia. Microinjection of 3 doses of trans-(+)-ACPD (100, 500 and 1000 pmol/100 nl) produced a dose-dependent fall in MAP (range, -20 to -50 mmHg) and HR (range, -30 to -170 bpm) under both conscious and chloralose anesthesia conditions. These data indicate that the cardiovascular responses to the activation of metabotropic receptors by trans-(+)-ACPD are not affected by chloralose anesthesia while the cardiovascular responses to the activation of excitatory amino acid (EAA) receptors by L-glutamate are significantly altered.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Pressão Sanguínea
/
Cloralose
/
Núcleo Solitário
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Ácido Glutâmico
/
Anestésicos Intravenosos
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Cicloleucina
/
Frequência Cardíaca
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1998
Tipo de documento:
Article
País de publicação:
Brasil