Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;30(2): 231-3, Feb. 1997. graf
Article
em En
| LILACS
| ID: lil-188431
Biblioteca responsável:
BR1.1
ABSTRACT
We investigated the long-lasting effect of peripheral injection of the neuropeptide substance P (SP) and of some N- or C-terminal SP fragments (SPN and SPC, respectively) on retention test performance of avoidance learning. Male Wistar rats (220 to 280 g) were trained in an inhibitory step-down avoidance task and tested 24 h or 21 days later. Immediately after the training trial rats received an intraperitoneal injection of SP (50 mug/kg), SPN 1-7 (l67 mug/kg) or SPC 7-11 (l34 mug/kg). Control groups were injected with vehicle or SP 5 h after the training trial. The immediate post-training administration of SP and SPN, but not SPC, facilitated avoidance behavior in rats tested 24 h or 21 days later, i.e., the retention test latencies of the SP and SPN groups were significantly longer (P<0.05, Mann-Whitney U-test) during both training-test intervals. These observations suggest that the memory-enhancing effect of SP is long-lasting and that the amino acid sequence responsible for this effect is encoded by its N-terminal part.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Aprendizagem da Esquiva
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Substância P
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Memória
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
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MEDICINA
Ano de publicação:
1997
Tipo de documento:
Article
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Project document
País de publicação:
Brasil