Reduced humoral immunity in uremic mice genetically selected for high antibody response
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;28(10): 1081-7, Oct. 1995. tab
Article
em En
| LILACS
| ID: lil-160999
Biblioteca responsável:
BR1.1
ABSTRACT
Biozzi's Selection IV-A mice, genetically selected for 25 generations for high and low antibody response to sheep red blood cells (SRBC), 2-3 months old, were made uremic by subtotal nephrectomy and characterized for antibody production against the selection antigen. T cell activity was evaluated in vitro by lymphocyte proliferation and interleukin 2 (IL 2) production in response to the superantigen staphylococcal enterotoxin B (SEB). Total and IgM antibody titers (log2) were similar in uremic and non-uremic low responder mice (total antobody 4.0 +/- 0.6 vs 3.6 +/- 0.6; IgG 3.0 +/- 0.7 vs 2.4 +/- 0,4), while uremic high responders presented a blunted humoral immune response to SRBC when compared with non-uremic animals (total antibody 10.8 +/- 1.6 vs 13.0 +/- 0.2; IgG 10.3 +/- 1.5 vs 11.7 +/- 0.3). T cell proliferation and IL 2 production were similar in uremic and ...
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Uremia
/
Técnicas In Vitro
/
Linfócitos T
/
Imunidade Celular
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1995
Tipo de documento:
Article
País de publicação:
Brasil