Maximum bronchodilator effect of pirbuterol and procaterol administered as sprays with and without an aerochamber
Rev. paul. med
; 111(3): 397-402, May-June 1993. tab
Article
em En
| LILACS
| ID: lil-127768
Biblioteca responsável:
BR1.1
ABSTRACT
Objective of the study To determine the maximal bronchodilator dose of procaterol and pirbuterol administered by inhalation with an without an aerochamber (Aerocâmera) to children with acute brinchial asthma attacks. Type of study Prospective. 18 children (6-15 years of age) with acute bronchial asthma attacks (FEV1 < 80 per cents of the predicted value) received pirbuterol (N = 10) or procaterol (N = 8) by metered-dose inhaler, one puff every 5 minutes, for a total of five doses. During another acute attack, the same patient received the same medication with the aid of a spacer (Aerocâmera). Clinical evaluation and pulmonary function tests were performed 5 minutes after each inhaled dose. Results:
For both drugs, maximal bronchodilation was obtained after the second dose. No significant side effects were observed even after procaterol doses of 50 µg or pirbuterol doses of 1000 µg. The results were unaffected by the use of the spacer.Conclusions:
The doses that induced maximal bronchodilation were 400 µg pirbuterol and 20 µg procaterol Although the spacer did not change the results, it is a valuable aid for patients who have difficulty in using the metered-dose inhaler (M.D.I.)
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Asma
/
Procaterol
/
Etanolaminas
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Humans
/
Male
Idioma:
En
Revista:
Rev. paul. med
Assunto da revista:
MEDICINA
Ano de publicação:
1993
Tipo de documento:
Article
País de publicação:
Brasil