Hepatic morphology changes after hepatic artery ligation in extrahepatic cholestasis

Castro e Silva Junior, O; Soares, A. F; Roselino, J. E. S; Ceneviva, R; Zucoloto, S

Castro e Silva Junior, O; Soares, A. F; Roselino, J. E. S; Ceneviva, R; Zucoloto, S.

Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;25(4): 353-5, 1992. tab

Article em En | LILACS | ID: lil-109039

Biblioteca responsável: BR26.1

ABSTRACT

ABSTRACT

The present study was performed to correlate changes in hepatic morphology with hepatic artery ligation (HAL) in the presence of extrahepatic cholestasis (EHC). The study was conducted on 36 male Wistar rats weighing 350 to 400 g, divided at random into four groups of 9 animals each group I, sham operation (control); group II, HAL; group III, bile duct ligation (BDL); group IV, HAL plus BDL. After seven days, liver fragments were obtained for morphiological study. The relative volume of the bile ducts was I>IIIV (P<0.05). These data indicate that arterial irrigation is important for the nutrition of the biliary tree. Seventy-six percent of the animals sumitted to HAL plus BDL showed hepatic necrosis. In general, the liver propably becomes more dependent on HA flow in the presence of EHC

Assuntos

Ratos; Artéria Hepática/anatomia & histologia; Colestase Extra-Hepática; Fígado/lesões; Necrose; Artéria Hepática/irrigação sanguínea; Embolia

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Coleções: 01-internacional Base de dados: LILACS Assunto principal: Colestase Extra-Hepática / Artéria Hepática / Fígado / Necrose Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 1992 Tipo de documento: Article País de publicação: Brasil

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