Undernutrition during suckling has no effect on the rat locomotor activity response to caffeine
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;25(2): 187-91, 1992. tab
Article
em En
| LILACS
| ID: lil-109017
Biblioteca responsável:
BR26.1
RESUMO
It is known that early malnutrition causes hyposensitivity to serotonergic, gabaergic, catecholaminergic and opioid stimulation. In the present study, we determined whether adult rats undernourished during suckling presented an altered response to caffeine admninistration in a locomotor actiovityyy test. Rats were undernourished during suckling by feeding their dams a 7% casein diet. During the same period, well-nourished dams were fed a 28% casein diet. Animals (90-100 days of age) were habituated to the apparatus. Thereaftert, a dose-response curve for caffeine (2.5, 10.0, 20.0, 40.0 and 120.0 umol/kg, ip) was determined. During handling sessions, undernourished rats presented lower activity scores than well-nourished animals (average values 44.2 ñ 16.4 vs 57.9 ñ 15.4). Well-nourished and undernourished rats responded in a similar way to caffeine administration by increasing the locomotor activity in a dose-dependent manner. Although undernourished animals present an altered sensitivity to various neuropharmacological compounds, the present results indicate that their sensitivity to the locomotor-actiivating effect of caffeine is the same as that of rats well-nourished during suckling
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Aleitamento Materno
/
Cafeína
/
Adenosina
/
Desnutrição Proteico-Calórica
/
Movimento
/
Distúrbios Nutricionais
Limite:
Animals
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1992
Tipo de documento:
Article
País de publicação:
Brasil