Insulin resistance in essential hypertension
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;23(12): 1253-7, 1990. tab
Article
em En
| LILACS
| ID: lil-103652
Biblioteca responsável:
BR1.1
ABSTRACT
To determine the possible existence of a relationship between insulin resistance and sympthetic nervous system activity in essential hypertension, we calculated the double cross index for 14 hypertensive sujects and 14 normotensive subjects submitted to the oral glucose test. Plasma glucose and insulin levels were similar in hypertensive and normotensive subjects. After glucose loading, however, both parameters were significantly higher in hypertensive subjects. Five out of 14 hypertensive patients were hyperinsulinemic. The increase in double cross index following a glucose load was significantly higher in normotensive volunteers than in hyperinsulinemic hypertensive subjects. No change in double cross index was observed in normoinsulinemic hypertensive subjects. Thus, insulin resistance, high blood glucose level, impairment of cardiac response and hyperinsulinemia are present in a significant portion of hypertensive patients. Hyperinsulinemia may contribute to hypertensión by stimulating sympathetic nervous system activity, by influencing the calcium transport across the cell membrane and/or by some other mechanism
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Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Sistema Nervoso Simpático
/
Glicemia
/
Resistência à Insulina
/
Hipertensão
/
Insulina
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Assunto da revista:
BIOLOGIA
/
MEDICINA
Ano de publicação:
1990
Tipo de documento:
Article
/
Congress and conference
País de publicação:
Brasil