Deteccion de secuencias homologas al gen env del virus del Tumor Mamario Murino (MMTV) en cancer de mama de pacientes argentinas / Detection of murine mammary tumor virus (MMTV) env gene-like sequences in breast cancer from Argentine patients
Medicina (B.Aires)
; 62(4): -323327, 2002. ilus, tab
Article
em Es
| BINACIS
| ID: bin-7720
Biblioteca responsável:
BR1.1
ABSTRACT
In the last years research on the possible viral etiology of human breast cancer has been revised. Previous studies have demonstrated the presence of a Mouse Mammary Tumor Virus (MMTV) env gene-like sequence in about 38% of breast cancers from American and Italian women; these sequences are generally absent in other tumors and in normal mammary tissue. In the present study we have analyzed the presence of a 250-bp sequence of the MMTV env gene in breast cancer biopsies from Argentine patients. The retroviral fragment was present in 31% (23/74) of the tumors, only in one normal mammary tissue and in none of the fibroadenomas analYzed. Peripheral blood mononuclear cells (PBMC) from 46 cancer patients were also analyzed; the sequence was found in 17% (2/12) of the PBMC from env positive tumor patients and in 3% (1/34) of the env negatives. The results from Argentine samples are similar to those from USA and Italy, where the breast cancer incidence is alike. These findings support the hypothesis of a viral agent involved in the genesis of this neoplasia and encourage the continuation of these studies (AU)
Texto completo:
1
Coleções:
06-national
/
AR
Base de dados:
BINACIS
Assunto principal:
Infecções Tumorais por Vírus
/
Neoplasias da Mama
/
Genes env
/
Vírus do Tumor Mamário do Camundongo
/
Infecções por Retroviridae
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Female
/
Humans
País/Região como assunto:
America do sul
/
Argentina
Idioma:
Es
Revista:
Medicina (B.Aires)
Ano de publicação:
2002
Tipo de documento:
Article