Effect of dexamethasone on nitric oxide (NO) production by cultured astrocytes

Lavista Llanos, S; Roldán, A

Lavista Llanos, S; Roldán, A.

Afiliação

Lavista Llanos, S; Instituto de Biología y Medicina Experimental. Buenos Aires. Argentina
Roldán, A; Instituto de Biología y Medicina Experimental. Buenos Aires. Argentina

Biocell ; 23(1): 29-35, Apr. 1999.

Article em En | BINACIS | ID: bin-6059

Biblioteca responsável: AR5.1

ABSTRACT

ABSTRACT

Glial cell-derived nitric oxide (NO.) and its regulation has significant implications for central nervous system pathophysiology. The aim of the present study was to determine the production of NO. by cultured rat astrocytes and peritoneal macrophages, and its regulation by glucocorticoids. Results corroborate the presence of both constitutive and induced NO. synthase (cNOS and iNOS) in astrocytes, while macrophages express only the inducible isoform. Dexamethasone was able to decrease NO. synthesis produced by induction of iNOS in macrophage and astrocyte phagocytosis, but not the NO. produced by the cNOS spontaneously expressed in cultured astrocytes

Assuntos

Animais; Ratos; Animais Recém-Nascidos; Astrócitos/citologia; Astrócitos/efeitos dos fármacos; Astrócitos; Células Cultivadas; Córtex Cerebral/citologia; Dexametasona/farmacologia; Glucocorticoides/farmacologia; Óxido Nítrico; Ratos Sprague-Dawley

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Coleções: 06-national / AR Base de dados: BINACIS Assunto principal: Dexametasona / Células Cultivadas / Córtex Cerebral / Astrócitos / Ratos Sprague-Dawley / Glucocorticoides / Animais Recém-Nascidos / Óxido Nítrico Limite: Animals Idioma: En Revista: Biocell Ano de publicação: 1999 Tipo de documento: Article

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