Fibronectin substrate induces shortening of in vitro neural crest cell mitotic cycle
Biocell
; 23(2): 119-124, Aug. 1999.
Article
em En
| BINACIS
| ID: bin-6052
Biblioteca responsável:
AR5.1
ABSTRACT
Neural crest cells (NCC) segregate from neural folds, swim through extracellular matrix, and differentiate in several cell types. During in vivo and in vitro dispersion, NCC display a substantial proliferative rate. Here, we have evaluated this biological behavior under the influence of different substrates. NCC exhibit the highest proliferative activity on fibronectin substrate, with shortening of the G1 period. This fact is reverted by specific antibody pre-treatment of the substrate. Taking into account that NCC migrate along narrow and restricted pathways rich in essential fibronectin, with high proliferative rates, these results indicate that the fibronectin pathway contributes to increase the cell number, leading to a high population pressure that could participate in the early dispersion of NCC
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Assunto principal:
Células Cultivadas
/
Fase G1
/
Fase G2
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Fase S
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Fibronectinas
/
Crista Neural
Limite:
Animals
Idioma:
En
Revista:
Biocell
Ano de publicação:
1999
Tipo de documento:
Article