Efecto combinado de angiotensina II, met-encefalina y acetilcolina administradas intracerebroventricularmente sobre la presión arterial media en ratas albinas. / [Combined effect of intracerebroventricular injections of angiotensin II, met-enkephalin and acetylcholine on mean arterial pressure in albino rats]
Acta Physiol. Pharmacol. Latinoam
; 38(1): 77-85, 1988.
Article
em Es
| BINACIS
| ID: bin-52358
Biblioteca responsável:
AR1.1
ABSTRACT
Single and combined effects of intracerebroventricular bolus injection of Ang. II (200 ng), ACh (6 micrograms) and met-enkephalin (50 micrograms) on mean arterial pressure (MAP), was tested in Sprague-Dawley albino rats. A metallic cannula was implanted in the third ventricle according to standard stereotaxic procedures under pentobarbital anesthesia (35 mg/kg). On the third day, the animal was anesthetized again, a carotid artery was cannulated and connected to a pressure transducer for recording of MAP. Ang. II increased MAP; ACh produced a significant increase in the initial 5 minutes after injection and met-enkephalin did not induce any significant changes in MAP. The combined effect showed interesting results. Instead of a potentiation of the rise in MAP, Ang. II and ACh, when given together, did not show any significant changes. Also, met-enkephalin blocked the hypertensive response due to Ang. II, if given combined. This is compatible with an inhibitory action of met-enkephalin on an angiotensinergic neuronal system. A simplified hypothetical model that explains the findings described above is proposed as a working hypothesis.
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Coleções:
06-national
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AR
Base de dados:
BINACIS
Tipo de estudo:
Prognostic_studies
Idioma:
Es
Revista:
Acta Physiol. Pharmacol. Latinoam
Ano de publicação:
1988
Tipo de documento:
Article
País de publicação:
Argentina