Effects of calcium and EDTA on rat skin capillary permeability and on its response to histamine, serotonin and bradykinin.
Acta Physiol. Pharmacol. Latinoam
; 39(3): 227-34, 1989.
Article
em En
| BINACIS
| ID: bin-51958
Biblioteca responsável:
AR1.1
ABSTRACT
Evans blue extravasation in rat skin was used to study the effects of Ca2+ and EDTA on vascular permeability and on its response to mediators of inflammation. Ca2+ induced a concentration-dependent decrease of vascular permeability. The opposite effect was seen with EDTA 0.2 mM or higher. Effects on vascular permeability of intradermically injected histamine 100 micrograms/ml, serotonin 5 micrograms/ml and bradykinin 5 micrograms/ml, were lower when Ca2+ 8 mM was injected in the same site, and higher when EDTA 2 mM was given. EDTA effects were inhibited by Ca2+. The results suggest that, in rat skin, Ca2+ decreases capillary permeability and its response to histamine, serotonin and bradykinin.
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Coleções:
06-national
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AR
Base de dados:
BINACIS
Idioma:
En
Revista:
Acta Physiol. Pharmacol. Latinoam
Ano de publicação:
1989
Tipo de documento:
Article
País de publicação:
Argentina