Sistema linfoide y deficiencia proteica. Diferenciación en timo y placas de Peyer. / [The lymphoid system and protein deficiency. Differentiation in the thymus and Peyers patches]
Medicina (B.Aires)
; 49(2): 162-5, 1989.
Article
em Es
| BINACIS
| ID: bin-51881
Biblioteca responsável:
AR2.1
ABSTRACT
A Thymuses from protein deprived rats present 1) a significant decrease in the absolute number of thymic cells bearing the CD5 phenotype (OX19+), as well as Thy 1.1 (OX7+). The predominant cell population was the one containing TdT (terminal deoxynucleotidyl transferase) as a sole marker 2) in severely protein deprived rats followed by refeeding during 9 and 21 days, the existence of a small population of cells containing TdT as a sole marker. The TdT+W3/13+ cell population was restored but the CD4+ subpopulation (W3/25+) exists in lower numbers than in the age-matched controls. B Severe protein deficiency at weaning, led to the presence in the Peyers patches of very immature B-cells mostly c mu+OX7s mu-. Protein refeeding reinitiated the differentiation process as follows 1) c mu+OX7+s mu- c mu-OX7-s mu+ as in the normal Peyers patches; 2) however, switching of sIgM to sIgA-bearing cells was altered; 3) a low absolute number of W3/13+ and W3/25+ T-cells (CD4+) was found. C Oral tolerance to dextrin evolved due to antigen specific CD8+ T-cells (found in Peyers patches, mesenteric lymph nodes and spleen) and could be transferred to normal recipients.
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Idioma:
Es
Revista:
Medicina (B.Aires)
Ano de publicação:
1989
Tipo de documento:
Article
País de publicação:
Argentina