Inmunorregulación del crecimiento tumoral en un sistema murino. / [Immunoregulation of tumor growth in a murine model]
Medicina (B.Aires)
; 49(3): 265-70, 1989.
Article
em Es
| BINACIS
| ID: bin-51844
Biblioteca responsável:
AR2.1
ABSTRACT
Different spleen and tumor cell factors modifying tumoral and metastatic growth were studied. Spleen cell culture supernatants (SCS) from small and large tumor-bearing mice enhanced tumor growth. After tumor surgery, tumor enhancement was only mediated by supernatants from large tumor resected mice. Tumor facilitation and angiogenic response were mediated by the same supernatants; different fractions for these two activities were characterized. T and non-T cells, depending on tumor burden, were responsible for the enhancing activity; but angiogenesis depended only on T cells. While augmentation of metastatic spread was produced by tumor antigens (soluble tumor extracts, tumor-cell supernatants, formolized tumor cells), primary tumor development was not modified by tumor-cell supernatants. Increased incidence of metastases was also mediated by SCS from tumor resected mice which had previously been inoculated with tumor antigens. Immune status of tumor-resected mice was evaluated by delayed-type hypersensitivity reaction. Tumor cell membranes enriched with cholesterol-hemisuccinate were able to increase anti-tumor immune response.
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Tipo de estudo:
Prognostic_studies
Idioma:
Es
Revista:
Medicina (B.Aires)
Ano de publicação:
1989
Tipo de documento:
Article
País de publicação:
Argentina