Renal function in the diabetic pregnant rats.
Acta Physiol. Pharmacol. Ther Latinoam
; 49(2): 65-70, 1999.
Article
em En
| BINACIS
| ID: bin-40136
Biblioteca responsável:
AR1.1
ABSTRACT
Diabetic nephropathy is associated with increased urinary albumin and reduce kallikrein excretion. Increased activity of the renal kallikrein-kinin system has been suggested as one of the possible mechanisms underlying diabetic hyperfiltration. The present study shown that the Kallikrein-kinin system is progressively increased in the diabetic-pregnant rats at 7, 14, 21 days; 48 and 7 days after pregnancy (P < 0.05 vs Control). However, this increase during diabetic pregnancy did not reached the levels of control pregnancy. On the other hand albumin excretion shown a significant and progressive renal damage in the diabetic state. These findings suggest that the diabetic pregnancy could impair the renal hemodynamic, but, on the other side could modulate the vasodilator system at pregnancy in the attempt to protect the fetus.
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Coleções:
06-national
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AR
Base de dados:
BINACIS
Idioma:
En
Revista:
Acta Physiol. Pharmacol. Ther Latinoam
Ano de publicação:
1999
Tipo de documento:
Article
País de publicação:
Argentina