Determinación por PCR de la asociación entre antígenos HLA clase II y pénfigo vulgar. / [PCR determination of an association between class II HLA and pemphigus vulgaris]
Medicina (B.Aires)
; 59(1): 28-32, 1999.
Article
em Es
| BINACIS
| ID: bin-40041
Biblioteca responsável:
AR2.1
ABSTRACT
Pemphigus vulgaris (PV) is an autoimmune blistering disease affecting the skin and mucous membranes. It is characterized by the presence of an autoantibody directed against desmoglein 3, which causes acantholysis and blister formation. In this study, we examined the HLA antigens of 30 caucasian argentinian patients compared with 199 controls. We used the PCR-SSO method (Polymerase Chain Reaction-Sequence Specific Oligonucleotide). We found that PV patients had significantly increased frequencies of HLA DR4 (RR = 3.80, P = 0.001) and HLA DR 14 (RR = 5.97, P = 0.0001). As in other populations, two associated alleles were found the first was DR beta 1*0402 (RR = 44.70, P = 10.7) and DQ beta 1*0302 (RR = 71.82, P = 10(-7)) and the second was DR beta 1*1401 (RR = 117.94, P = 10(-7)) y DQ beta 1*0503 (RR = 86.95, P = 10(-7)).
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Coleções:
06-national
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AR
Base de dados:
BINACIS
Tipo de estudo:
Risk_factors_studies
Idioma:
Es
Revista:
Medicina (B.Aires)
Ano de publicação:
1999
Tipo de documento:
Article
País de publicação:
Argentina